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Abstract #0216

Calibration of BOLD fMRI motor activation maps using BOLD breath hold cerebrovascular reactivity mapping for effective compensation of brain tumor-related neurovascular uncoupling

Shruti Agarwal 1 , Raag Airan 1 , Sachin K. Gujar 1 , Haris I. Sair 1 , and Jay J. Pillai 1

1 Division of Neuroradiology, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States

Reduced or impaired cerebrovascular reactivity (CVR) in patients with brain tumors and other cerebral diseases can generate false negative or spuriously decreased BOLD fMRI activation during performance of presurgical mapping of motor and language cortex in patients who are potentially candidates for lesion resection. This phenomenon, referred to as neurovascular uncoupling (NVU) is an under-recognized but nevertheless critical limitation of clinical BOLD fMRI. In this study we demonstrate the feasibility of minimization of false negative motor task-based activation through use of a novel breath-hold CVR-based calibration method to effectively compensate for NVU in patients with perirolandic low grade gliomas.

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