Abstract #0216
Calibration of BOLD fMRI motor activation maps using BOLD breath hold cerebrovascular reactivity mapping for effective compensation of brain tumor-related neurovascular uncoupling
Shruti Agarwal 1 , Raag Airan 1 , Sachin K. Gujar 1 , Haris I. Sair 1 , and Jay J. Pillai 1
1
Division of Neuroradiology, Russell H.
Morgan Department of Radiology and Radiological Science,
Johns Hopkins University School of Medicine, Baltimore,
Maryland, United States
Reduced or impaired cerebrovascular reactivity (CVR) in
patients with brain tumors and other cerebral diseases
can generate false negative or spuriously decreased BOLD
fMRI activation during performance of presurgical
mapping of motor and language cortex in patients who are
potentially candidates for lesion resection. This
phenomenon, referred to as neurovascular uncoupling
(NVU) is an under-recognized but nevertheless critical
limitation of clinical BOLD fMRI. In this study we
demonstrate the feasibility of minimization of false
negative motor task-based activation through use of a
novel breath-hold CVR-based calibration method to
effectively compensate for NVU in patients with
perirolandic low grade gliomas.
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