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Abstract #0219

A streamlined approach to mapping the oxygen extraction fraction (OEF) and deoxygenated blood volume (DBV) using the quantitative BOLD technique

Alan J Stone 1 and Nicholas P Blockley 1

1 FMRIB, Nuffield Department of Clinical Neurosciences, Oxford, United Kingdom

There is a need for an easy-to-implement MR method capable of providing quantitative parametric maps of OEF and DBV across the brain in a clinically feasible timescale. In this study a FLAIR GESEPI ASE sequence is used to provide a refined measure of R 2 ′ through optimisation of the data acquisition. The components of the sequence are selected to minimise confounds associated with CSF partial volume effects (FLAIR), macroscopic field inhomogeneities (GESEPI) and R 2 -weighting (ASE) of the R 2 ′ signal. This affords a simplified application of the qBOLD signal model, allowing parametric maps of OEF and DBV to be produced in a streamlined process.

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