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Abstract #0218

Baseline oxygenation in the brain: Correlation with BOLD and comparison between susceptibility and respiratory-calibration methods

Audrey P. Fan 1 , Andreas Schaefer 2 , Laurentius Huber 2 , Steffen N. Krieger 2 , Harald E. Moeller 2 , Arno Villringer 2 , and Claudine J. Gauthier 2,3

1 Richard M. Lucas Center for Imaging, Stanford University, Stanford, CA, United States, 2 Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, 3 Concordia University, Montreal, Quebec, Canada

This study investigated whether BOLD signal changes during visual stimulus and gas challenge depend on baseline oxygen extraction fraction (OEF 0 ), as measured by quantitative susceptibility mapping (QSM) in cerebral veins. We also directly compared absolute OEF 0 values in the visual cortex by QSM and by a novel respiratory-calibration method (QUO2). In eight healthy volunteers, BOLD-ASL scans were acquired during gas breathing and visual stimulus, and gradient echo scans were acquired at rest for QSM reconstruction. Good fidelity was observed between BOLD-ASL signal changes and baseline OEF 0 by QSM, as predicted by biophysical models. Our findings also reveal encouraging concordance between absolute OEF 0 by QSM (30.62%) and by QUO2 (31.512%) that warrants examination in a larger cohort.

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