Abstract #0218
Baseline oxygenation in the brain: Correlation with BOLD and comparison between susceptibility and respiratory-calibration methods
Audrey P. Fan 1 , Andreas Schaefer 2 , Laurentius Huber 2 , Steffen N. Krieger 2 , Harald E. Moeller 2 , Arno Villringer 2 , and Claudine J. Gauthier 2,3
1
Richard M. Lucas Center for Imaging,
Stanford University, Stanford, CA, United States,
2
Max
Planck Institute for Human Cognitive and Brain Sciences,
Leipzig, Germany,
3
Concordia
University, Montreal, Quebec, Canada
This study investigated whether BOLD signal changes
during visual stimulus and gas challenge depend on
baseline oxygen extraction fraction (OEF
0
),
as measured by quantitative susceptibility mapping (QSM)
in cerebral veins. We also directly compared absolute
OEF
0
values
in the visual cortex by QSM and by a novel
respiratory-calibration method (QUO2). In eight healthy
volunteers, BOLD-ASL scans were acquired during gas
breathing and visual stimulus, and gradient echo scans
were acquired at rest for QSM reconstruction. Good
fidelity was observed between BOLD-ASL signal changes
and baseline OEF
0
by
QSM, as predicted by biophysical models. Our findings
also reveal encouraging concordance between absolute OEF
0
by
QSM (30.62%) and by QUO2 (31.512%) that warrants
examination in a larger cohort.
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