Meeting Banner
Abstract #0221

Diffusion Weighted MRI for Early Detection and Progression Monitoring of Prostate Cancer in a Transgenic Mouse Model

Deborah K. Hill 1,2 , Eugene Kim 1,2 , Jose R. Teruel 1,2 , Siver A. Moestue 1,2 , and Tone F. Bathen 1

1 Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Sr Trndelag, Norway, 2 St. Olavs University Hospital, Trondheim, Sr Trndelag, Norway

The effectiveness of DW-MRI for both detecting early onset of prostate cancer (PCa) and for characterising disease progression was investigated for the transgenic adenocarcinoma of the mouse prostate (TRAMP) model in mice. DWI facilitated early detection of tumour onset in TRAMP mice prostates before lesions were seen on high-resolution T2W images. Histograms are sensitive to distinguishing cancer from prostate tissue, where bimodal distributions were clearly visible in the case of cancer onset. Median ADC values of prostate regions were in agreement with literature values for different stages of PCa progression, thus providing a non-invasive means to assess cancer aggressiveness.

This abstract and the presentation materials are available to members only; a login is required.

Join Here