Meeting Banner
Abstract #0222

In vivo and ex vivo diffusion tensor imaging parameters follow Collagen 1 fiber distribution in breast cancer xenograft model

Samata M Kakkad 1,2 , Jiangyang Zhang 1 , Alireza Akhbardeh 1 , Desmond Jacob 1 , Meiyappan Solaiyappan 1 , Michael A Jacobs 1 , Venu Raman 1 , Dieter Leibfritz 2 , Kristine Glunde 1 , and Zaver M Bhujwalla 1

1 Radiology, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2 University of Bremen, Bremen, Germany

Col1 fibers play an important role in molecular transport and cancer cell dissemination. We investigated the influence of Col1 fibers on water diffusion, using a breast cancer xenograft fluorescing under hypoxia. We observed that hypoxic regions contained significantly fewer Col1 fibers, and were characterized by a lower ADC and FA compared to normoxic tumor regions. In vivo DTI distribution patterns were spatially similar to those observed ex vivo, suggesting that noninvasive DTI parameters provided noninvasive indices of Col1 fiber distribution in tumors.

This abstract and the presentation materials are available to members only; a login is required.

Join Here