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Abstract #0223

Investigating the Impact of a Primary Tumor on Metastasis and Dormancy Using MRI: New Insights into the Mechanism of Concomitant Tumor Resistance

Paula Foster 1,2 , Amanda Hamilton 1 , and Carmen Simedrea 1

1 Imaging, Robarts Research Institute, London, Ontario, Canada, 2 Medical Biophysics, Western University, London, Ontario, Canada

MRI was used to track growth of brain metastases and dormant (non proliferative) cancer cells in a mouse model of concomitant tumor resistance. Our major result was that the presence of a primary mammary fat pad tumor limited the development of secondary metastases in the brain.

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