In-vivo quantification of iron oxide nanoparticles at high concentration in a murine breast tumor model using positive contrast
Jinjin Zhang 1 , Alicia A. Petryk 2 , Russell Reeves 3 , Djaudat Idiyatullin 1 , Hattie L. Ring 1,4 , P. Jack Hoopes 2,3 , and Michael Garwood 1
Center for Magnetic Resonance Research,
Department of Radiology, University of Minnesota,
Minneapolis, MN, United States,
School of Engineering, Dartmouth College, NH, United
School of Medicine, Dartmouth College, NH, United
of Chemistry, University of Minnesota, MN, United States
The ability to accurately and sensitively image tumor
iron oxide nanoparticles (IONPs) is essential for their
use as a therapeutic modality in clinical cancer
medicine. In this study, the quantification of IONPs in
a murine breast tumor model at high, but clinically
relevant, concentrations was done by using positive
contrast from SWIFT sequence. IONPs were administered by
intra-tumoral (IT) or intravenous (IV) injection.
Polyethylene glycol (PEG) and low dose radiation
enhanced IONP tumor uptake. The T1 maps measured by the
SWIFT sequence provided quantitative and qualitative
estimations of IONP at concentrations significantly
higher (x30) than previously reported.
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