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Abstract #0225

In-vivo quantification of iron oxide nanoparticles at high concentration in a murine breast tumor model using positive contrast

Jinjin Zhang 1 , Alicia A. Petryk 2 , Russell Reeves 3 , Djaudat Idiyatullin 1 , Hattie L. Ring 1,4 , P. Jack Hoopes 2,3 , and Michael Garwood 1

1 Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN, United States, 2 Thayer School of Engineering, Dartmouth College, NH, United States, 3 Geisel School of Medicine, Dartmouth College, NH, United States, 4 Department of Chemistry, University of Minnesota, MN, United States

The ability to accurately and sensitively image tumor iron oxide nanoparticles (IONPs) is essential for their use as a therapeutic modality in clinical cancer medicine. In this study, the quantification of IONPs in a murine breast tumor model at high, but clinically relevant, concentrations was done by using positive contrast from SWIFT sequence. IONPs were administered by intra-tumoral (IT) or intravenous (IV) injection. Polyethylene glycol (PEG) and low dose radiation enhanced IONP tumor uptake. The T1 maps measured by the SWIFT sequence provided quantitative and qualitative estimations of IONP at concentrations significantly higher (x30) than previously reported.

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