Combined PET-MRI: is it possible to quantify FDG perfusion based on Gd-DTPA pharmacokinetics?
Marie Anne Richard 1 , Vincent Turgeon 1 , Jrmie P. Fouquet 1 , Luc Tremblay 1 , Rjean Lebel 1 , and Martin Lepage 1
Centre dimagerie molculaire de Sherbrooke
(CIMS), Universit de Sherbrooke, Sherbrooke, Qubec,
Signal in PET imaging is modulated by the perfusion and
metabolism of the radiotracer. It would be possible to
decouple these parameters through combined PET-MRI using
an unmetabolized MRI contrast agent with similar
perfusion kinetics as the radiotracer. Sequential MRI
and PET scans were performed in rats using Gd-DTPA and
FDG. Pharmacokinetic parameters were extracted based on
a two-tissue model and statistical analysis was
performed to determine if perfusion and elimination are
correlated between both probes. Preliminary results
suggest that perfusion is correlated, whereas
elimination is not.
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