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Abstract #0226

Combined PET-MRI: is it possible to quantify FDG perfusion based on Gd-DTPA pharmacokinetics?

Marie Anne Richard 1 , Vincent Turgeon 1 , Jrmie P. Fouquet 1 , Luc Tremblay 1 , Rjean Lebel 1 , and Martin Lepage 1

1 Centre dimagerie molculaire de Sherbrooke (CIMS), Universit de Sherbrooke, Sherbrooke, Qubec, Canada

Signal in PET imaging is modulated by the perfusion and metabolism of the radiotracer. It would be possible to decouple these parameters through combined PET-MRI using an unmetabolized MRI contrast agent with similar perfusion kinetics as the radiotracer. Sequential MRI and PET scans were performed in rats using Gd-DTPA and FDG. Pharmacokinetic parameters were extracted based on a two-tissue model and statistical analysis was performed to determine if perfusion and elimination are correlated between both probes. Preliminary results suggest that perfusion is correlated, whereas elimination is not.

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