Combined PET-MRI: is it possible to quantify FDG perfusion based on Gd-DTPA pharmacokinetics?

Signal in PET imaging is modulated by the perfusion and metabolism of the radiotracer. It would be possible to decouple these parameters through combined PET-MRI using an unmetabolized MRI contrast agent with similar perfusion kinetics as the radiotracer. Sequential MRI and PET scans were performed in rats using Gd-DTPA and FDG. Pharmacokinetic parameters were extracted based on a two-tissue model and statistical analysis was performed to determine if perfusion and elimination are correlated between both probes. Preliminary results suggest that perfusion is correlated, whereas elimination is not.

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