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Abstract #0227

Dynamic Contrast Enhanced Magnetic Resonance Imaging Evaluates Early Therapeutic Effect of Anti-EMMPRIN Antibody with Cisplatin or X-radiation in Head and Neck Cancer Mouse Models

Hyunki Kim 1 , Yolanda Hartman 1 , Guihua Zhai 1 , Thomas Chung 1 , Melissa Korb 1 , Tong Zhou 1 , and Eben Rosenthal 1

1 University of Alabama at Birmingham, Birmingham, AL, United States

Dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) showed that tumor microvascular perfusion was significantly suppressed by anti-EMMPRIN antibody alone or in combination with X-radiation or cisplatin in head and neck cancer mouse models. The early change of tumor perfusion parameters following anti-EMMPRIN therapy with/without cisplatin was significantly correlated with the tumor volume change, proliferation cell density, and microvessel density, but not when X-radiation treated group was included. Therefore DCE-MRI may be used to predict the therapeutic efficacy of anti-EMMPRIN antibody with/without cisplatin, but not with X-radiation.

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