Effect of oxygen challenge on MR imaging of tumor microenvironment

Few studies have been performed to reveal the changes of tumor microenvironment such as diffusion and perfusion parameters in response to oxygen challenge. The purpose of this study was to evaluate the effect of oxygen challenge on tumor heterogeneity, diffusion and perfusion parameters at the microscopic level. The current study demonstrated that IVIM diffusion MRI provided powerful insight into tumor perfusion. On the other hand, diffusion stretched-exponential model was sensitive to the changes of tumor heterogeneity, Combining these two models may serve as potential biomarker to evaluate tumor responses to oxygen.

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