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Abstract #0232

Differentiation of Early-Stage Parkinsonisms with Diffusion Kurtosis Imaging Using The Diffusion Magnetic Resonance Parkinsonism Index

Kenji Ito 1 , Makoto Sasaki 1 , Chigumi Ohtuka 2 , Suguru Yokosawa 3 , Taisuke Harada 1 , Ikuko Uwano 1 , Fumio Yamashita 1 , Satomi Higuchi 1 , and Yasuo Terayama 2

1 Division of Ultrahigh Field MRI, Institute for Biomedical Sciences, Iwate Medical University, Yahaba, Iwate, Japan, 2 Department of Neurology and Gerontology, Iwate Medical University, Morioka, Iwate, Japan, 3 Central Research Laboratory, Hitachi, Ltd., Kokubunji, Tokyo, Japan

The differential diagnosis of early-stage parkinsonisms, such as Parkinsonfs disease, multiple system atrophy, and progressive supranuclear palsy is often difficult. Hence, we investigated whether diffusion kurtosis imaging (DKI) with a quantitative imaging marker, the diffusion magnetic resonance parkinsonism index (dMRPI), can help to differentiate between these disorders. The dMRPI of mean kurtosis (MK) differed significantly among the patients compared to the dMRPI of fractional anisotropy/mean diffusivity, conventional MRPI, and 123I-metaiodobenzylguanidine scintigraphy. The sensitivities and specificities of dMRPI-MK for the differentiations were both over 80%. This quantitative index can therefore contribute to early differential diagnoses of neurodegenerative disorders showing parkinsonism.

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