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Abstract #0231

Can MRI of the nigrosomes provide a biomarker for progression of Parkinsons Disease?

Stefan Schwarz 1 , Olivier Mougin 1 , Yue Xing 1 , Ania Blazejewska 1 , Lesley Martin 1 , Nin Bajaj 2 , Dorothee Auer 1 , and Penny Gowland 1

1 Sir Peter Mansfield Imaging Cetre, University of Nottingham, Nottingham, Nottinghamshire, United Kingdom, 2 Division of Neurology, Nottingham University Hospitals NHS Trust, Nottingham, Nottinghamshire, United Kingdom

Nigrosomes 1-5 can be detected at 7T and are less visible in PD patients than in controls. The laterality of loss of the nigrosomes correlates better with disease laterality than DaTscan results for this group. The variation in nigrosome visibility and nigrsome T2*w signal with log(UPDRS) suggests that these measures may provide a quantitative biomarker of PD progression.

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