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Abstract #0230

Diagnosis of Early-stage Idiopathic Parkinsons Disease: Feasibility of Nigrosome 1 Imaging at 3T

Eung Yeop Kim 1 , Young Noh 2 , Young-Hee Sung 2 , and Jongho Lee 3

1 Radiology, Gachon University Gil Medical Center, Incheon, ., Korea, 2 Neurology, Gachon University Gil Medical Center, Incheon, ., Korea, 3 Electrical and Computer Engineering, Seoul National University, Seoul, ., Korea

In the early stage of IPD, patients often present asymmetric motor symptoms. We hypothesized that dopaminergic cell loss is observable by the structural change in the region of the nigrosome 1 at 3T MRI. We acquired DAT PET data and 3T MRI data from 24 early-stage IPD patients and correlated the laterality of the imaging results with the patient symptoms. The abnormality involving the nigrosome 1 can be detected at 3T MRI with accuracy of 94.6%. The clinical laterality is in higher concordance with the laterality on nigrosome 1 MRI at 3T than that on dopamine transporter PET.

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