Abstract #0230
Diagnosis of Early-stage Idiopathic Parkinsons Disease: Feasibility of Nigrosome 1 Imaging at 3T
Eung Yeop Kim 1 , Young Noh 2 , Young-Hee Sung 2 , and Jongho Lee 3
1
Radiology, Gachon University Gil Medical
Center, Incheon, ., Korea,
2
Neurology,
Gachon University Gil Medical Center, Incheon, ., Korea,
3
Electrical
and Computer Engineering, Seoul National University,
Seoul, ., Korea
In the early stage of IPD, patients often present
asymmetric motor symptoms. We hypothesized that
dopaminergic cell loss is observable by the structural
change in the region of the nigrosome 1 at 3T MRI. We
acquired DAT PET data and 3T MRI data from 24
early-stage IPD patients and correlated the laterality
of the imaging results with the patient symptoms. The
abnormality involving the nigrosome 1 can be detected at
3T MRI with accuracy of 94.6%. The clinical laterality
is in higher concordance with the laterality on
nigrosome 1 MRI at 3T than that on dopamine transporter
PET.
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