Abstract #0234
Deterioration of neuronal and glial intermediary metabolism, neurochemical profiles and brain morphology in insulin-resistant Goto-Kakizaki rats: a multimodal magnetic resonance study in vivo
Freya-Merret Girault 1 , Rolf Gruetter 1,2 , and Joao M.N. Duarte 1
1
LIFMET, EPFL, Lausanne, Vaud, Switzerland,
2
Radiology,
UNIL and UNIGE, Lausanne and Geneva, Vaud, Switzerland
Insulin signalling deregulation in diabetes deteriorates
brain structure and function leading to cognitive
deficits. We performed a longitudinal multimodal
magnetic resonance imaging (MRI) and spectroscopy (
1
H
and
13
C
MRS) study in insulin-resistant Goto-Kakizaki and
control Wistar rats, as well as behavioural analyses, to
elucidate early brain metabolic modifications associated
to memory impairment in diabetes. We concluded that
altered brain energy metabolism induced neurochemical
alterations that were associated with the degree of
brain dysfunction, namely impaired memory performance.
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