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Abstract #0234

Deterioration of neuronal and glial intermediary metabolism, neurochemical profiles and brain morphology in insulin-resistant Goto-Kakizaki rats: a multimodal magnetic resonance study in vivo

Freya-Merret Girault 1 , Rolf Gruetter 1,2 , and Joao M.N. Duarte 1

1 LIFMET, EPFL, Lausanne, Vaud, Switzerland, 2 Radiology, UNIL and UNIGE, Lausanne and Geneva, Vaud, Switzerland

Insulin signalling deregulation in diabetes deteriorates brain structure and function leading to cognitive deficits. We performed a longitudinal multimodal magnetic resonance imaging (MRI) and spectroscopy ( 1 H and 13 C MRS) study in insulin-resistant Goto-Kakizaki and control Wistar rats, as well as behavioural analyses, to elucidate early brain metabolic modifications associated to memory impairment in diabetes. We concluded that altered brain energy metabolism induced neurochemical alterations that were associated with the degree of brain dysfunction, namely impaired memory performance.

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