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Abstract #0235

Diffusion tensor imaging and contrast-enhanced MRI of the eye and the central visual pathway in streptozotocin-induced diabetes

Swarupa Kancherla 1 , Ed X. Wu 2 , and Kevin C. Chan 1,3

1 Department of Ophthalmology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States, 2 Department of Electrical and Electronic Engineering, The University of Hong Kong, Pokfulam, Hong Kong, China, 3 Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States

This study used diffusion tensor imaging, manganese-enhanced MRI, and chromium-enhanced MRI to evaluate the structure and physiology of the visual system in experimental diabetes, and elucidate the initial structures compromised in streptozotocin (STZ)-induced type 1 diabetic rats. Our results suggest that STZ-induced type 1 diabetes leads to structural changes of the distal optic nerve before MRI-detectable changes in retina, optic tract, superior colliculus, or lateral geniculate nucleus.

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