Abstract #0235
Diffusion tensor imaging and contrast-enhanced MRI of the eye and the central visual pathway in streptozotocin-induced diabetes
Swarupa Kancherla 1 , Ed X. Wu 2 , and Kevin C. Chan 1,3
1
Department of Ophthalmology, School of
Medicine, University of Pittsburgh, Pittsburgh,
Pennsylvania, United States,
2
Department
of Electrical and Electronic Engineering, The University
of Hong Kong, Pokfulam, Hong Kong, China,
3
Department
of Bioengineering, Swanson School of Engineering,
University of Pittsburgh, Pittsburgh, Pennsylvania,
United States
This study used diffusion tensor imaging,
manganese-enhanced MRI, and chromium-enhanced MRI to
evaluate the structure and physiology of the visual
system in experimental diabetes, and elucidate the
initial structures compromised in streptozotocin
(STZ)-induced type 1 diabetic rats. Our results suggest
that STZ-induced type 1 diabetes leads to structural
changes of the distal optic nerve before MRI-detectable
changes in retina, optic tract, superior colliculus, or
lateral geniculate nucleus.
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