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Abstract #0236

Investigation of glymphatic impairment in diabetes using MRI and distributed RC line model

Esmaeil Davoodi Bojd 1 , Li Zhang 1 , Guangliang Ding 1 , Siamak Nejad-Davarani 1 , ZhengGang Zhang 1 , Lian Li 1 , QingJiang Li 1 , Michael Chopp 1 , and Quan Jiang 1

1 Neurology, Henry Ford Health System, Detroit, Michigan, United States

This work demonstrates the first investigation of glymphatic impairment after diabetes in rat using MRI. Gd-DTPA contrast agent is used to monitor the glymphatic pathways by MR imaging. Using an equivalent electrical circuit for the glymphatic system, the clearance rate of CA from the brain is estimated. The results show that the CA remains much longer in diabetic brain than normal one. This means that the CSF moves slower in diabetic rats. The proposed approach can be used to determine quantitatively the effect of treatment after neurological disorder, such as diabetes.

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