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Abstract #0237

SWI monitoring iron tagged dextran transportation in normal and hydrocephalus rat brains via intrathecal delivery

Satish Krishnamurthy 1 , Jie Li 1 , Yimin Shen 2 , and E Mark Haacke 2

1 Department of Neurosurgery, SUNY Upstate Medical University, Syracuse, NY, United States, 2 Radiology, Wayne state university, Detroit, MI, United States

We hypothesized that macromolecular transportation is altered in communicating hydrocephalus rats. SWI was used to monitoring iron tagged dextran transportation in rat brains via intraventricular delivery. Fe-Dextran clearance time depended on the dose. Distribution kinetics of Fe-Dextran in cerebral ventricles and parenchyma was clearly different in hydrocephalus rats compared to normal rats. The tracer entering the brain tissue via para-arterial pathways was rapidly cleared and did not build up in the brain parenchyma or vessel wall for normal rats while there was an obvious delay in clearance with a significant increase in Fe-Dextran in the veins for the hydrocephalus rats.

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