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Abstract #0238

Blood-Brain-Barrier Permeability and Lesion Volume Changes in Acute Japanese Macaque Encephalomyelitis

Ian Tagge 1,2 , Steven Kohama 3 , Jim Pollaro 1 , Lawrence Sherman 3 , Dennis Bourdette 4 , Randy Woltjer 4 , Scott Wong 3 , and William Rooney 1,2

1 Advanced Imaging Research Center, Oregon Health & Science University, Portland, Oregon, United States, 2 Biomedical Engineering, Oregon Health & Science University, Portland, OR, United States, 3 Oregon National Primate Research Center, Oregon Health & Science University, Oregon, United States, 4 Neurology, Oregon Health & Science University, Portland, Oregon, United States

Dynamic-contrast-enhanced magnetic resonance imaging (DCE-MRI) provides a unique method of quantitatively characterizing neurovascular properties in-vivo. Pharmacokinetic modeling of DCE-MRI data allows quantification of vascular properties, such as BBB permeability, that are sensitive to disease state. Japanese Macaque Encephalomyelitis (JME) is a spontaneous non-human primate analog of human MS. We adopted a short-term longitudinal study design to investigate lesion morphological and microvascular changes in acute JME. Lesions are observed to be fairly stable within approximately 24 hrs, but substantial changes can occur in as few as 3 days. Acute lesions with elevated BBB permeability arise from NABT rapidly (< 7 days).

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