Abstract #0239
Metabolism Reflects Progressive HIV-1 Associated Neuropathology in Humanized Mice
Michael D. Boska 1 , Prasanta K. Dash 2 , Jaclyn Knibbe 2 , Adrian A. Epstein 1,2 , Robin High 3 , Edward Makarov 2 , Harris A. Gelbard 4 , Larisa Poluektova 2 , Howard E. Gendelman 2 , and Santhi Gorantla 2
1
Radiology, University of Nebraska Medical
Center, Omaha, NE, United States,
2
Pharmacology
and Experimental Neurosciences, University of Nebraska
Medical Center, Omaha, NE, United States,
3
College
of Public Health, Biostatistics, University of Nebraska
Medical Center, Omaha, NE, United States,
4
5Department
of Neurology, Center for Neural Development and Disease,
University of Rochester Medical Center, Rochester, NY,
United States
Peripheral systemic HIV-1 infection in mice containing a
human immune system was studied to determine effects of
long term infection on brain metabolism and
neuropathology. Cortical reductions of synapses and
oligodendrocyte function correlated to alterations in
N-acetyl aspartate, creatine, myoinostitol, and
glutamate. Alterations in creatine and NAA show the
opposing effects of synaptic loss and loss of
oligodendrocyte function. These results can be used to
address some of the variability in spectroscopic results
found in literature reports from HIV-1 infected animals
and patients.
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