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Abstract #0239

Metabolism Reflects Progressive HIV-1 Associated Neuropathology in Humanized Mice

Michael D. Boska 1 , Prasanta K. Dash 2 , Jaclyn Knibbe 2 , Adrian A. Epstein 1,2 , Robin High 3 , Edward Makarov 2 , Harris A. Gelbard 4 , Larisa Poluektova 2 , Howard E. Gendelman 2 , and Santhi Gorantla 2

1 Radiology, University of Nebraska Medical Center, Omaha, NE, United States, 2 Pharmacology and Experimental Neurosciences, University of Nebraska Medical Center, Omaha, NE, United States, 3 College of Public Health, Biostatistics, University of Nebraska Medical Center, Omaha, NE, United States, 4 5Department of Neurology, Center for Neural Development and Disease, University of Rochester Medical Center, Rochester, NY, United States

Peripheral systemic HIV-1 infection in mice containing a human immune system was studied to determine effects of long term infection on brain metabolism and neuropathology. Cortical reductions of synapses and oligodendrocyte function correlated to alterations in N-acetyl aspartate, creatine, myoinostitol, and glutamate. Alterations in creatine and NAA show the opposing effects of synaptic loss and loss of oligodendrocyte function. These results can be used to address some of the variability in spectroscopic results found in literature reports from HIV-1 infected animals and patients.

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