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Abstract #0258

Blood oxygen level dependent (BOLD) and diffusion tensor (DTI) imaging of the kidneys in patients with Type 1 diabetes: preliminary clinical experience with reference to healthy control subjects

Elissa Botterill 1 , Windell Ang 1 , Jas-mine Seah 1 , Claire Mulcahy 2 , Elif Ekinci 1,3 , George Jerums 1,3 , Richard MacIsaac 3,4 , Pippa Storey 5 , Eric Sigmund 5 , Tim Spelman 6 , and Ruth P Lim 1,3

1 Austin Health, Melbourne, Victoria, Australia, 2 The Florey Institute of Neuroscience and Mental Health, Melbourne, Victoria, Australia, 3 The University of Melbourne, Melbourne, Victoria, Australia, 4 St Vincent's Hospital, East Melbourne, Victoria, Australia, 5 CAIIR, Bernard and Irene Schwartz Center for Biomedical Imaging, NYU School of Medicine, New York, NY, United States, 6 Burnet Institute, Melbourne, Victoria, Australia

Reliable identification of diabetic kidney disease (DKD) in Type 1 diabetic patients (T1DM) and prediction of disease progression is challenging. BOLD and diffusion tensor imaging (DTI) has potential to non-invasively evaluate renal function and microstructure. 25 T1DM with a) normal and b) low eGFR, and c) 10 healthy controls were recruited for BOLD and DTI at 3T. No differences were seen in medullary or cortical R2* values, and ADC between the three groups. Significant differences were seen with medullary and cortical FA in T1DM with low eGFR. DTI may be a promising tool for identification and monitoring of DKD.

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