Abstract #0258
Blood oxygen level dependent (BOLD) and diffusion tensor (DTI) imaging of the kidneys in patients with Type 1 diabetes: preliminary clinical experience with reference to healthy control subjects
Elissa Botterill 1 , Windell Ang 1 , Jas-mine Seah 1 , Claire Mulcahy 2 , Elif Ekinci 1,3 , George Jerums 1,3 , Richard MacIsaac 3,4 , Pippa Storey 5 , Eric Sigmund 5 , Tim Spelman 6 , and Ruth P Lim 1,3
1
Austin Health, Melbourne, Victoria,
Australia,
2
The
Florey Institute of Neuroscience and Mental Health,
Melbourne, Victoria, Australia,
3
The
University of Melbourne, Melbourne, Victoria, Australia,
4
St
Vincent's Hospital, East Melbourne, Victoria, Australia,
5
CAIIR,
Bernard and Irene Schwartz Center for Biomedical
Imaging, NYU School of Medicine, New York, NY, United
States,
6
Burnet
Institute, Melbourne, Victoria, Australia
Reliable identification of diabetic kidney disease (DKD)
in Type 1 diabetic patients (T1DM) and prediction of
disease progression is challenging. BOLD and diffusion
tensor imaging (DTI) has potential to non-invasively
evaluate renal function and microstructure. 25 T1DM with
a) normal and b) low eGFR, and c) 10 healthy controls
were recruited for BOLD and DTI at 3T. No differences
were seen in medullary or cortical R2* values, and ADC
between the three groups. Significant differences were
seen with medullary and cortical FA in T1DM with low
eGFR. DTI may be a promising tool for identification and
monitoring of DKD.
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