Abstract #0269
Single-Shot Whole-Brain Background-Suppressed pCASL MRI with 1D Accelerated 3D RARE Stack-Of-Spirals Readout
Marta Vidorreta 1 , Ze Wang 2,3 , Yulin V. Chang 1,4 , Mara A. Fernndez-Seara 5 , and John A. Detre 1
1
Department of Neurology, University of
Pennsylvania, Philadelphia, Pennsylvania, United States,
2
Center
for Cognition and Brain Disorders, Hangzhou Normal
University, Hangzhou, Zhejiang Province, China,
3
Departments
of Radiology and Psychiatry, University of Pennsylvania,
Philadelphia, Pennsylvania, United States,
4
Department
of Radiology, University of Pennsylvania, Pennsylvania,
United States,
5
Functional
Neuroimaging Laboratory, CIMA, University of Navarra,
Navarra, Spain
Recent technical developments have increased the SNR of
ASL perfusion data, enabling whole-brain,
high-resolution ASL imaging by combining
pseudo-continuous labeling, background suppression and
3D segmented readouts. However, segmented acquisitions
are sub-optimal for studying dynamic perfusion changes.
This work proposes the use of a twofold accelerated 3D
RARE Stack-Of-Spirals readout to enable single-shot,
high-SNR, whole-brain ASL imaging with a nominal voxel
resolution of 3.75mm isotropic. Results in 6 volunteers
during the performance of a motor-photic task show an
increase in GM-WM contrast with no associated SNR
penalty and no loss in activation sensitivity, likely
due to the increased perfusion signal level and
decreased through-plane blurring achieved by the
shortening of readout time.
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