Meeting Banner
Abstract #0269

Single-Shot Whole-Brain Background-Suppressed pCASL MRI with 1D Accelerated 3D RARE Stack-Of-Spirals Readout

Marta Vidorreta 1 , Ze Wang 2,3 , Yulin V. Chang 1,4 , Mara A. Fernndez-Seara 5 , and John A. Detre 1

1 Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, United States, 2 Center for Cognition and Brain Disorders, Hangzhou Normal University, Hangzhou, Zhejiang Province, China, 3 Departments of Radiology and Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, United States, 4 Department of Radiology, University of Pennsylvania, Pennsylvania, United States, 5 Functional Neuroimaging Laboratory, CIMA, University of Navarra, Navarra, Spain

Recent technical developments have increased the SNR of ASL perfusion data, enabling whole-brain, high-resolution ASL imaging by combining pseudo-continuous labeling, background suppression and 3D segmented readouts. However, segmented acquisitions are sub-optimal for studying dynamic perfusion changes. This work proposes the use of a twofold accelerated 3D RARE Stack-Of-Spirals readout to enable single-shot, high-SNR, whole-brain ASL imaging with a nominal voxel resolution of 3.75mm isotropic. Results in 6 volunteers during the performance of a motor-photic task show an increase in GM-WM contrast with no associated SNR penalty and no loss in activation sensitivity, likely due to the increased perfusion signal level and decreased through-plane blurring achieved by the shortening of readout time.

This abstract and the presentation materials are available to members only; a login is required.

Join Here