Single-shot 3D-EPI PCASL with background suppression
Markus Boland 1 , Rdiger Stirnberg 1 , Daniel Brenner 1 , and Tony Stcker 1,2
German Center for Neurodegenerative Diseases
(DZNE), Bonn, Germany,
of Physics and Astronomy, University of Bonn, Germany
A single-shot 3D-EPI PCASL sequence with background
suppression and variable flip angle excitations was
implemented and compared to PCASL with 3D-GRASE readout.
With 3D-EPI we observed reduced blurring in slice
direction and similar SNR compared to single-shot
3D-GRASE. Therefore the method might be a good candidate
for functional ASL applications. For static CBF
quantification at 3 mm isometric resolution the use of
variable flip angles showed significant increase of SNR
and CNR for the 3D-EPI, however, a segmented 3D-GRASE
acquisition still provides about 15% higher SNR and CNR
in the same acquisition time.
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