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Abstract #0268

Single-shot 3D-EPI PCASL with background suppression

Markus Boland 1 , Rdiger Stirnberg 1 , Daniel Brenner 1 , and Tony Stcker 1,2

1 German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany, 2 Department of Physics and Astronomy, University of Bonn, Germany

A single-shot 3D-EPI PCASL sequence with background suppression and variable flip angle excitations was implemented and compared to PCASL with 3D-GRASE readout. With 3D-EPI we observed reduced blurring in slice direction and similar SNR compared to single-shot 3D-GRASE. Therefore the method might be a good candidate for functional ASL applications. For static CBF quantification at 3 mm isometric resolution the use of variable flip angles showed significant increase of SNR and CNR for the 3D-EPI, however, a segmented 3D-GRASE acquisition still provides about 15% higher SNR and CNR in the same acquisition time.

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