Multiband background suppressed turbo-FLASH imaging with CAIPIRINHA for whole-brain distortion-free pCASL imaging at 3 and 7T
Yi Wang 1 , Steen Moeller 2 , Xiufeng Li 2 , An T Vu 2 , Kate Krasileva 1 , Kamil Ugurbil 2 , Essa Yacoub 2 , and Danny JJ Wang 1
Neurology, UCLA, Los Angeles, CA, United
of Magnetic Resonance Research, University of Minnesota,
MN, United States
Multiband imaging has recently been attempted for
arterial spin labeled perfusion MRI using EPI readout.
It was found that MB-EPI can reduce T1 relaxation of the
label, improve image coverage and resolution with little
penalty in SNR. However, EPI still suffers from
geometric distortion and signal dropout from field
inhomogeneity effects especially at high fields. Here we
present a novel scheme for achieving high fidelity
distortion-free quantitative perfusion imaging by
combining pCASL with MB-Turbo-FLASH readout at both 3
and 7T. We demonstrated the feasibility for whole brain
distortion-free quantitative mapping of cerebral blood
flow at high and ultrahigh magnetic fields.
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