Wedge-shaped slice-selective adiabatic inversion pulse for bolus temporal width control in pulsed arterial spin labeling

The Turbo-QUASAR strategy proposed by Petersen and colleagues to improve the temporal signal-to-noise (tSNR) of arterial spin labeling (ASL) experiments works optimally when the temporal width of the tagged boluses matches the inter-pulse spacing. However, this cannot be accomplished using a conventional labeling slab because the feeding arteries will generally have different velocities and geometries. In order to remedy this, we propose a novel labeling strategy by creating a wedge-shaped (WS) inversion slab using additional in-plane gradients with minimal reduction in its adiabaticity. The WS inversion pulse may potentially be used to control and match the bolus temporal width in different feeding arteries, maximizing the tSNR in fast Pulsed ASL measurements.

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