An off-resonance correction method for vessel-encoded pseudo-continuous arterial spin labeling using the optimized encoding scheme

Vessel-encoded pseudo-continuous arterial spin labeling (VEPCASL) can trace the flow patterns of individual feeding arteries in the brain. Unipolar VEPCASL produces a sinusoidal-like variation in inversion efficiency across the plane where blood is labeled. In the presence of a B0-induced frequency offset the inversion efficiency remains constant but its spatial position is shifted. If unaccounted for this can lead to reduced SNR and errors in the separation of signals from different arteries. Here we present a method that incorporates a correction for off-resonance at the vessel locations into a method for optimizing the encoding schemes for multiple vessels.

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