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Abstract #0281

Quantitative Susceptibility Mapping of Lesions in Multiple Sclerosis

Ahmed M. Elkady 1 , Hongfu Sun 1 , Andrew J. Walsh 1 , Gregg Blevins 2 , Zhuozhi Dai 1 , and Alan H. Wilman 1

1 Dept. of Biomedical Engineering, University of Alberta, Edmonton, AB, Canada, 2 Division of Neurology, University of Alberta, Edmonton, AB, Canada

Susceptibility (SUS), Local Field Shift (LFS), and R2* conspicuity and contrast of 351 lesions were examined in 20 Multiple Sclerosis (MS) patients. Although the majority were not visible in SUS or LFS, visible lesions mostly appeared as hyper-core with no ring. Perls iron stain of 22 lesions in two postmortem MS subjects were also examined in pathology sections and matched to lesions conspicuity and contrast in registered in situ MRI. Results indicated that hyper-core lesion contrast in LFS or SUS and dipole field patterns in LFS could confirm the presence of iron, but could not predict iron absence.

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