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Abstract #0282

Measurement of the Oxygen Extraction Fraction in Patients with Steno-occlusive Cerebrovascular Diseases using Quantitative Susceptibility Mapping at 7T

Ikuko Uwano 1 , Makoto Sasaki 1 , Kohsuke Kudo 2 , Ryota Sato 3 , Yuiko Sato 4 , Yasushi Ogasawara 4 , Hiroaki Saura 4 , Kuniaki Ogasawara 4 , Taisuke Harada 1 , Kenji Ito 1 , Fumio Yamashita 1 , Jonathan Goodwin 1 , and Satomi Higuchi 1

1 Division of Ultrahigh Field MRI, Institute for Biomedical Sciences, Iwate Medical University, Yahaba, Iwate, Japan, 2 Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Sapporo, Hokkaido, Japan, 3 Central Research Laboratory, Hitachi, Ltd., Kokubunji, Tokyo, Japan, 4 Department of Neurosurgery, Iwate Medical University, Morioka, Iwate, Japan

This study aims to determine the accuracy of oxygen extraction fraction (OEF) maps generated from quantitative susceptibility mapping (QSM) at 7T. We compared relative OEF values of the affected cerebral hemisphere against the contralateral hemisphere between QSM and PET in patients with chronic unilateral internal carotid artery or middle cerebral artery stenosis/occlusion. Relative QSM-OEF values showed excellent agreements with the corresponding PET-OEF values. Therefore, OEF measurement using QSM at 7T is considered comparable to that using PET and can be applied for the assessment of patients with steno-occlusive cerebrovascular diseases.

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