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Abstract #0285

High Conspicuity Imaging and Initial Quantification of the Habenula on 3T QSM Images of Normal Human Brain

John Schenck 1 , Dominic Graziani 1 , Ek Tsoon Tan 1 , Seung-Kyun Lee 1 , Luca Marinelli 1 , Thomas Foo 1 , Christopher Hardy 1 , Tian Liu 2 , and Yi Wang 3

1 MRI Laboratory, General Electric Global Research, Schenectady, New York, United States, 2 MedImageMetric, New York, New York, United States, 3 Radiology, Cornell Medical College, New York, New York, United States

The habenular nuclei are two small (mm-sized) cell masses deep in the brain near the midline on either side of the 3rd ventricle. They are currently of intense neuropsychological interest as they have been implicated as having major roles in normal brain functioning and in serious psychiatric disorders (e.g., depression). However, they are not normally seen as conspicuous brain components on conventional MRI images. We have demonstrated that using QSM imaging on normal volunteers using a conventional 3T scanner the habenulae can be identified and quantified as conspicuous, paramagnetic iron-rich structures.

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