Meeting Banner
Abstract #0286

Susceptibility Mapping in Sickle Cell Anaemia Patients With and Without Chronic Blood Transfusions

Karin Shmueli 1 , Jamie M Kawadler 2 , David W Carmichael 2 , Chris A Clark 2 , and Fenella J Kirkham 3

1 Department of Medical Physics & Biomedical Engineering, University College London, London, United Kingdom, 2 Imaging & Biophysics Unit, UCL Institute of Child Health, London, United Kingdom, 3 Neurosciences Unit, UCL Institute of Child Health, London, United Kingdom

Sickle cell anaemia (SCA) is a genetic disorder affecting haemoglobin. Previous studies suggest that the iron content in some deep-brain regions is higher in transfused SCA patients (TSCA) than in healthy controls (HC). We hypothesised that iron content in those regions is lower in non-transfused patients (NSCA) than in controls as NSCA have low haematocrit. A pilot study (5 TSCA, 5 NSCA, 5 HC) showed that susceptibility values were significantly lower in the globus pallidus of both TSCA and NSCA than in HC, supporting our second hypothesis. A larger study (20 NSCA, 18 HC) showed a trend in this direction.

This abstract and the presentation materials are available to members only; a login is required.

Join Here