Abstract #0286
Susceptibility Mapping in Sickle Cell Anaemia Patients With and Without Chronic Blood Transfusions
Karin Shmueli 1 , Jamie M Kawadler 2 , David W Carmichael 2 , Chris A Clark 2 , and Fenella J Kirkham 3
1
Department of Medical Physics & Biomedical
Engineering, University College London, London, United
Kingdom,
2
Imaging
& Biophysics Unit, UCL Institute of Child Health,
London, United Kingdom,
3
Neurosciences
Unit, UCL Institute of Child Health, London, United
Kingdom
Sickle cell anaemia (SCA) is a genetic disorder
affecting haemoglobin. Previous studies suggest that the
iron content in some deep-brain regions is higher in
transfused SCA patients (TSCA) than in healthy controls
(HC). We hypothesised that iron content in those regions
is lower in non-transfused patients (NSCA) than in
controls as NSCA have low haematocrit. A pilot study (5
TSCA, 5 NSCA, 5 HC) showed that susceptibility values
were significantly lower in the globus pallidus of both
TSCA and NSCA than in HC, supporting our second
hypothesis. A larger study (20 NSCA, 18 HC) showed a
trend in this direction.
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