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Abstract #0288

Imaging Magnetic Susceptibility of the Human Knee Joint at 3 and 7 Tesla

Hongjiang Wei 1 , Bin Wang 1 , Xiaopeng Zong 2 , Weili Lin 2 , Nian Wang 1 , and Chunlei Liu 1,3

1 Brain Imaging and Analysis Center, Duke University, Durham, NC, United States, 2 Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, NC, United States, 3 Depatment of Radoilogy, School of Medicine, Duke University, NC, United States

The knee joint is one of the most important joints in the human body with several intricate structures and complex interfaces including bones, tendons, muscles, fat, ligaments, cartilages and meniscuses. Each of these components has unique molecular and cellular composition and microstructures and thus may exhibit varying magnetic susceptibility. Quantitative susceptibility mapping (QSM) has been widely investigated in the brain, e.g. for quantifying iron deposits and myelination. However, these techniques have not been successfully implemented in the knee. The purpose of this work was to develop and demonstrate feasibility of water-fat separated QSM in the knee as well as to evaluate the susceptibility properties of different anatomical structures within the knee joint. Imaging susceptibility of the knee may aid in assessing knee joint diseases and disorders.

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