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Abstract #0289

Perfusion/Diffusion mismatch in stroke: what about the hematocrit?

Benjamin Lemasson 1,2 , Alexis Broisat 3,4 , Ligia S. B. Boisserand 1,2 , Mitra Ahmadi 3,4 , Sandrine Bacot 3,4 , Audrey Soubies 3,4 , Olivier Detante 1,5 , Catherine Ghezzi 3,4 , Chantal Rmy 1,2 , and Emmanuel L. Barbier 1,2

1 Inserm, U836, Grenoble, -, France, 2 Univ. Grenoble Alpes, GIN, Grenoble, -, France, 3 Inserm, U1039, Grenoble, -, France, 4 Univ. Grenoble Alpes, Radiopharmaceutiques Biocliniques, Grenoble, -, France, 5 CHU de Grenoble, GIN, Grenoble, -, France

MRI and molecular imaging techniques were associated to map the perfusion (CBF)/diffusion (ADC) mismatch and the local hematocrit level (Hct) of rats during actute stroke. The stroke lesion drawn on the CBF maps were significantly larger than the ones drawn on the ADC maps which were themselves significantly larger than the ones drawn on the Hct maps (ROIs sizes: CBF>ADC>Hct). The mismatch between CBF and Hct suggests that plasmatic and red blood cell flows are not equivalent during acute stroke. The ADC/Hct mismatch might be used to determine a new region of tissue, which could be able to recover.

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