Abstract #0297
Intravoxel Incoherent Motion Imaging exposes abnormal parenchyma and microvasculature in cerebral small vessel disease
Sau May Wong 1 , Eleana Zhang 2 , Frank C.G. Bussel 1 , Julie E.A. Staals 2 , Ccile R.L.P.N. Jeukens 1 , Paul A.M. Hofman 1 , Robert J. van Oostenbrugge 2 , Walter H. Backes 1 , and Jacobus F.A. Jansen 1
1
Radiology, Maastricht University Medical
Center, Maastricht, Limburg, Netherlands,
2
Neurology,
Maastricht University Medical Center, Maastricht,
Limburg, Netherlands
Cerebral small vessel disease(cSVD) affects the small
vessels in the brain, which can potentially lead to
ischemic stroke and dementia. The pathophysiology
remains unclear. Intravoxel incoherent motion
imaging(IVIM) was performed to examine both the
parenchymal and vascular microstructure in cSVD.
Significant higher microvascular perfusion fraction(f)
and parenchymal diffusivity(D) were found for patients
in normal appearing brain tissue compared with controls.
Higher f might be related to more tortuous vessels and
higher D might imply loss of parenchymal microstructural
integrity in cSVD. We demonstrate the potential of IVIM
in providing novel information of the brain tissue in
cSVD.
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