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Abstract #0297

Intravoxel Incoherent Motion Imaging exposes abnormal parenchyma and microvasculature in cerebral small vessel disease

Sau May Wong 1 , Eleana Zhang 2 , Frank C.G. Bussel 1 , Julie E.A. Staals 2 , Ccile R.L.P.N. Jeukens 1 , Paul A.M. Hofman 1 , Robert J. van Oostenbrugge 2 , Walter H. Backes 1 , and Jacobus F.A. Jansen 1

1 Radiology, Maastricht University Medical Center, Maastricht, Limburg, Netherlands, 2 Neurology, Maastricht University Medical Center, Maastricht, Limburg, Netherlands

Cerebral small vessel disease(cSVD) affects the small vessels in the brain, which can potentially lead to ischemic stroke and dementia. The pathophysiology remains unclear. Intravoxel incoherent motion imaging(IVIM) was performed to examine both the parenchymal and vascular microstructure in cSVD. Significant higher microvascular perfusion fraction(f) and parenchymal diffusivity(D) were found for patients in normal appearing brain tissue compared with controls. Higher f might be related to more tortuous vessels and higher D might imply loss of parenchymal microstructural integrity in cSVD. We demonstrate the potential of IVIM in providing novel information of the brain tissue in cSVD.

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