Abstract #0298
Transient cerebral ischemia in rodents exposed to chronic intermittent hypoxia
Bianca Gonzales Cerqueira 1 , Yuhao Sun 1 , Shiliang Huang 1 , Glenn Toney 2 , and Timothy Q Duong 1
1
Research Imaging Institute, Univ. of TX
Health Science Center, San Antonio, TX, United States,
2
Physiology,
Univ. of TX Health Science Center, TX, United States
There is controversy in literature on whether prior
exposure to chronic intermittent hypoxia (CIH), a model
of sleep apnea, is detrimental to or neuroprotective
against transient cerebral ischemia. In this study, we
exposed rats to 14-day CIH of 10% O2 and induced
60-minute cerebral ischemia using middle cerebral artery
occlusion. CBF, ADC, and T2 lesion volumes were
calculated up to 14 days post stroke. CBF stroke lesion
volumes at 30 minutes were the same between controls and
CIH-exposed animals. ADC and T2 lesion volumes were
significantly larger in the CIH-exposed group as
compared to controls in all time points studied.
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