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Abstract #0298

Transient cerebral ischemia in rodents exposed to chronic intermittent hypoxia

Bianca Gonzales Cerqueira 1 , Yuhao Sun 1 , Shiliang Huang 1 , Glenn Toney 2 , and Timothy Q Duong 1

1 Research Imaging Institute, Univ. of TX Health Science Center, San Antonio, TX, United States, 2 Physiology, Univ. of TX Health Science Center, TX, United States

There is controversy in literature on whether prior exposure to chronic intermittent hypoxia (CIH), a model of sleep apnea, is detrimental to or neuroprotective against transient cerebral ischemia. In this study, we exposed rats to 14-day CIH of 10% O2 and induced 60-minute cerebral ischemia using middle cerebral artery occlusion. CBF, ADC, and T2 lesion volumes were calculated up to 14 days post stroke. CBF stroke lesion volumes at 30 minutes were the same between controls and CIH-exposed animals. ADC and T2 lesion volumes were significantly larger in the CIH-exposed group as compared to controls in all time points studied.

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