Abstract #0315
Assessment of Extracellular Matrix Degradation in Intervertebral Disc Degeneration by Diffusion Weighted MRS and Chemical Exchange Saturation Transfer
Anna M. WANG 1,2 , Adrian Tsang 1,2 , and Ed X. Wu 1,2
1
Laboratory of Biomedical Imaging and Signal
Processing, Hong Kong, Hong Kong, Hong Kong,
2
Department
of Electrical and Electronic Engineering, The University
of Hong Kong, Hong Kong, Hong Kong, Hong Kong
This study compared the capability of diffusion weighted
MRS (DW-MRS) and chemical exchange saturation transfer
(CEST) methods in detecting and characterizing the ECM
degradation during the early stage of IVDD in an ex vivo
model. The apparent diffusion coefficient (ADC) of
glycosaminoglycan (GAG) increased drastically
immediately after papain injection, while the GAG
concentration measured by both MRS and CEST method
shared a similar but slow decreasing trend which
happened later than the GAG ADC increase. The GAG ADC
value, which is free from the influence of the GAG
concentration, is an important potential marker for
detecting the onset of the ECM degradation in IVDD.
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