Assessment of glycosaminoglycan content in lumbar intervertebral discs with chemical exchange saturation transfer imaging: comparison with T1-rho measurement
Osamu Togao 1 , Akio Hiwatashi 1 , Tatsuhiro Wada 2 , Koji Yamashita 1 , Kazufumi Kikuchi 1 , Chiaki Tokunaga 2 , Yuriko Suzuki 3 , Jochen Keupp 4 , and Hiroshi Honda 1
Clinical Radiology, Graduate School of
Medical Sciences, Kyushu University, Fukuoka, Fukuoka,
of Radiology, Department of Medical Technology, Kyushu
University Hospital, Fukuoka, Fukuoka, Japan,
Electronics Japan, Tokyo, Japan,
Research, Hamburg, Germany
Glycosaminoglycan CEST (gagCEST) imaging is an emerging
molecular MR imaging technique to directly measure
in-vivo GAG content in cartilaginous tissue. In this
study, we demonstrated the utility of this method in
assessments of lumbar intervertebral disc (IVD)
degeneration by comparing with T1-rho, an established
quantitative biomarker of IDD, and conventional
morphological assessments. GagCEST correlated with
T1-rho and Pfirrmann grades in lumbar IVD degeneration.
GagCEST can provide a quantitative measure to assess
degeneration of IVDs.
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