Abstract #0317
Assessment of glycosaminoglycan content in lumbar intervertebral discs with chemical exchange saturation transfer imaging: comparison with T1-rho measurement
Osamu Togao 1 , Akio Hiwatashi 1 , Tatsuhiro Wada 2 , Koji Yamashita 1 , Kazufumi Kikuchi 1 , Chiaki Tokunaga 2 , Yuriko Suzuki 3 , Jochen Keupp 4 , and Hiroshi Honda 1
1
Clinical Radiology, Graduate School of
Medical Sciences, Kyushu University, Fukuoka, Fukuoka,
Japan,
2
Division
of Radiology, Department of Medical Technology, Kyushu
University Hospital, Fukuoka, Fukuoka, Japan,
3
Philips
Electronics Japan, Tokyo, Japan,
4
Philips
Research, Hamburg, Germany
Glycosaminoglycan CEST (gagCEST) imaging is an emerging
molecular MR imaging technique to directly measure
in-vivo GAG content in cartilaginous tissue. In this
study, we demonstrated the utility of this method in
assessments of lumbar intervertebral disc (IVD)
degeneration by comparing with T1-rho, an established
quantitative biomarker of IDD, and conventional
morphological assessments. GagCEST correlated with
T1-rho and Pfirrmann grades in lumbar IVD degeneration.
GagCEST can provide a quantitative measure to assess
degeneration of IVDs.
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