Spatial maps of DCEMRI enhancement in endplates of degenerating intervertebral discs reveal major pathologic changes
Volkan Emre Arpinar 1 , Ali Ersoz 2 , and L Tugan Muftuler 1,3
Department of Neurosurgery, Medical College
of Wisconsin, Milwaukee, Wisconsin, United States,
of Boiphysics, Medical College of Wisconsin, Wisconsin,
for Imaging Research, Medical College of Wisconsin,
Wisconsin, United States
Nutrient transport to the discs through the endplate
region was studied using Dynamic Contrast Enhanced MRI.
Data were acquired from subjects with varying degrees of
disc degeneration. Spatial maps of contrast enhancement
were generated for each endplate and subchondral bone
region in the lumbar area. A template for vertebral body
disc surface interface was generated and enhancement
maps were registered to this template for analysis
across all subjects and all lumbar levels. Average
enhancement maps were calculated for healthy, moderately
degenerated and highly degenerated discs and the results
revealed major pathologic changes in the endplate
regions as the discs degenerate.
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