Towards Targeted Molecular Imaging of Colorectal Cancer by Hyperpolarized Silicon Particles Functionalized with Mucin Antibody
Jingzhe Hu 1,2 , Nicholas Whiting 3 , Pamela Constantinou 4 , Niki Zacharias Millward 3 , David Menter 5 , Daniel Carson 4 , and Pratip Bhattacharya 3
Bioengineering, Rice University, Houston,
TX, United States,
Anderson Cancer Center, Houston, TX, United States,
Systems Imaging, MD Anderson Cancer Center, Houston, TX,
Rice University, Houston, TX, United States,
Biology, MD Anderson Cancer Center, Houston, TX, United
We aim to develop a real-time molecular MR imaging
platform to diagnose colorectal cancer with silicon
particles functionalized with mucin (MUC1) antibodies.
These silicon particles can be hyperpolarized via
Dynamic Nuclear Polarization, leading to a potential
signal increase of over 10,000 fold. Here, we present
preliminary data showing that the antibody
functionalization can survive the cryogenic temperature
required by DNP (~3.7 K) and the binding affinity was
not adversely affected in vitro. We have also
successfully imaged hyperpolarized PEGylated-silicon
particles in vivo following intraperitoneal injection,
paving the way for targeted molecular MRI of orthotopic
colon cancer models.
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