Abstract #0321
Towards Targeted Molecular Imaging of Colorectal Cancer by Hyperpolarized Silicon Particles Functionalized with Mucin Antibody
Jingzhe Hu 1,2 , Nicholas Whiting 3 , Pamela Constantinou 4 , Niki Zacharias Millward 3 , David Menter 5 , Daniel Carson 4 , and Pratip Bhattacharya 3
1
Bioengineering, Rice University, Houston,
TX, United States,
2
MD
Anderson Cancer Center, Houston, TX, United States,
3
Cancer
Systems Imaging, MD Anderson Cancer Center, Houston, TX,
United States,
4
BioSciences,
Rice University, Houston, TX, United States,
5
Cancer
Biology, MD Anderson Cancer Center, Houston, TX, United
States
We aim to develop a real-time molecular MR imaging
platform to diagnose colorectal cancer with silicon
particles functionalized with mucin (MUC1) antibodies.
These silicon particles can be hyperpolarized via
Dynamic Nuclear Polarization, leading to a potential
signal increase of over 10,000 fold. Here, we present
preliminary data showing that the antibody
functionalization can survive the cryogenic temperature
required by DNP (~3.7 K) and the binding affinity was
not adversely affected in vitro. We have also
successfully imaged hyperpolarized PEGylated-silicon
particles in vivo following intraperitoneal injection,
paving the way for targeted molecular MRI of orthotopic
colon cancer models.
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