Abstract #0320
Dynamic in vivo free radical imaging with Overhauser-enhanced MRI
Mathieu Sarracanie 1,2 , Fanny Herisson 3 , Najat Salameh 1,2 , David E J Waddington 1,4 , Cenk Ayata 3 , and Matthew S Rosen 1,2
1
MGH/A.A. Martinos Center for Biomedical
Imaging, Charlestown, MA, United States,
2
Department
of Physics, Harvard University, Cambridge, MA, United
States,
3
Neurovascular
Research Lab, Department of Radiology, Massachusetts
General Hospital, Charlestown, United States,
4
ARC
Center for Engineered Quantum Systems, School of
Physics, University of Sydney, Sydney, NSW, Australia
We explore the use of b-SSFP based OMRI to acquire free
radical images with sufficient spatial and temporal
resolution to probe oxidative stress status via free
radical decay dynamics in the rat brain. We present here
time-resolved OMRI following a single injection of
TEMPOL in healthy living rats. Sixteen full 11 slice
OMRI data sets were acquired over 240s at 6.5mT. Free
radical contrast is clearly seen in the hemisphere
ipsilateral to the injection. The results presented here
suggest that temporally resolved OMRI in conjunction
with an exogenous free radical agent may allow study the
redox status of brain tissue.
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