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Abstract #0320

Dynamic in vivo free radical imaging with Overhauser-enhanced MRI

Mathieu Sarracanie 1,2 , Fanny Herisson 3 , Najat Salameh 1,2 , David E J Waddington 1,4 , Cenk Ayata 3 , and Matthew S Rosen 1,2

1 MGH/A.A. Martinos Center for Biomedical Imaging, Charlestown, MA, United States, 2 Department of Physics, Harvard University, Cambridge, MA, United States, 3 Neurovascular Research Lab, Department of Radiology, Massachusetts General Hospital, Charlestown, United States, 4 ARC Center for Engineered Quantum Systems, School of Physics, University of Sydney, Sydney, NSW, Australia

We explore the use of b-SSFP based OMRI to acquire free radical images with sufficient spatial and temporal resolution to probe oxidative stress status via free radical decay dynamics in the rat brain. We present here time-resolved OMRI following a single injection of TEMPOL in healthy living rats. Sixteen full 11 slice OMRI data sets were acquired over 240s at 6.5mT. Free radical contrast is clearly seen in the hemisphere ipsilateral to the injection. The results presented here suggest that temporally resolved OMRI in conjunction with an exogenous free radical agent may allow study the redox status of brain tissue.

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