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Abstract #0323

Application of Goods buffers to pH imaging using hyperpolarized 13C-MRI

Robert R Flavell 1 , David Korenchan 1 , Cornelius von Morze 1 , Mark Van Criekinge 1 , Renuka Sriram 1 , Sukumar Subramaniam 1 , Robert Bok 1 , Joseph Blecha 1 , Daniel Vigneron 1 , Peder Larson 1 , Kayvan R Keshari 2 , John Kurhanewicz 1 , and David M Wilson 1

1 Radiology and biomedical imaging, University of California, San Francisco, San Francisco, CA, United States, 2 Memorial Sloan-Kettering Cancer Center, New York, NY, United States

Solid tumors have numerous mechanisms to export acid into the extracellular space, resulting in a low interstitial pH. In this abstract we report a novel method for imaging this property using hyperpolarized 13C,15N ACES, a commonly used biological buffer. ACES demonstrates remarkable pH dependent chemical shift change over the physiologic range. Application to phantom imaging and preliminary in vivo imaging experiments will be presented. This method combines the large 13C chemical shifts of HP ACES in the physiologic range, with the dramatic signal enhancements afforded by dissolution dynamic nuclear polarization (DNP).

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