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Abstract #0324

Dynamic imaging of hyperpolarized 6 Li cerebral distribution at pharmacological concentration

Mor Mishkovsky 1 , Andrea Capozzi 2 , Najat Salameh 2 , Jean-Noel Hyacinthe 3 , Rolf Gruetter 1,4 , and Arnaud Comment 2

1 Laboratory of Functional and Metabolic Imaging, Ecole Polytechnique Fdrale de Lausanne (EPFL), Lausanne, Switzerland, 2 Institute of the Physics of Biological Systems, Ecole Polytechnique Fdrale de Lausanne (EPFL), Lausanne, Switzerland, 3 Haute Ecole de Sant, University of Applied Sciences Western Switzerland, Geneva, Switzerland, 4 Center of biomedical imaging (CIBM), Ecole Polytechnique Fdrale de Lausanne (EPFL), Lausanne, Switzerland

Hyperpolarization by dissolution dynamic nuclear polarization (DNP) allows enhancing the signal intensity of insensitive nuclear spins such as 6 Li. The long in vivo T 1 of 6 Li makes it an attractive hyperpolarized contrast agent for real-time perfusion imaging. The present study demonstrates the feasibility of imaging in real time the cerebral distribution of hyperpolarized 6 Li at pharmaceutical concentration. As lithium salt is used for treating bipolar disorder, this opens new opportunities to assess the effect of Li + on cerebral function.

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