Abstract #0326
Flow-sensitizing gradients for first-pass perfusion imaging using hyperpolarized 13C urea in the rat heart
Angus Z Lau 1,2 , Jack J Miller 2,3 , and Damian J Tyler 1,2
1
Department of Cardiovascular Medicine,
University of Oxford, Oxford, Oxfordshire, United
Kingdom,
2
Department
of Physiology, Anatomy, and Genetics, University of
Oxford, Oxford, Oxfordshire, United Kingdom,
3
Department
of Physics, University of Oxford, Oxford, Oxfordshire,
United Kingdom
We investigate the feasibility of imaging the first
passage of a bolus of hyperpolarized
13
C
urea through the rat heart. We propose to use
flow-sensitizing bipolar gradients to null the bright
signal within the cardiac chambers. An ECG-gated, golden
angle spiral pulse sequence is used to obtain dynamic
images of
13
C
urea in the heart (2.3x2.3x5 mm
3
resolution,
TR~150 ms). Flow-sensitization results in black-blood
contrast that enables direct visualization of
hyperpolarized
13
C
urea within the tissue capillary bed. Our results
demonstrate reduced contamination from the cardiac
lumen.
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