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Abstract #0329

Magnetic Resonance Fingerprinting with Chemical Exchange (MRF-X) for Quantification of Subvoxel T1, T2, Volume Fraction, and Exchange Rate

Jesse I. Hamilton 1 , Anagha Deshmane 1 , Stephanie Hougen 2 , Mark Griswold 1,3 , and Nicole Seiberlich 1,3

1 Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, 2 Physics, Case Western Reserve University, Cleveland, OH, United States, 3 Radiology, Case Western Reserve University, Cleveland, OH, United States

A new technique termed MRF-X is introduced that models two-compartment chemical exchange to generate a dictionary for subvoxel mapping of T1, T2, volume fraction, and exchange rate. Simulations indicate that the MRF-X model can map subvoxel parameters in cases where standard mapping sequences would map a single effective T1 or T2 value. MRF-X has the potential to directly measure properties of tissue microstructure.

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