Abstract #0329
Magnetic Resonance Fingerprinting with Chemical Exchange (MRF-X) for Quantification of Subvoxel T1, T2, Volume Fraction, and Exchange Rate
Jesse I. Hamilton 1 , Anagha Deshmane 1 , Stephanie Hougen 2 , Mark Griswold 1,3 , and Nicole Seiberlich 1,3
1
Biomedical Engineering, Case Western Reserve
University, Cleveland, OH, United States,
2
Physics,
Case Western Reserve University, Cleveland, OH, United
States,
3
Radiology,
Case Western Reserve University, Cleveland, OH, United
States
A new technique termed MRF-X is introduced that models
two-compartment chemical exchange to generate a
dictionary for subvoxel mapping of T1, T2, volume
fraction, and exchange rate. Simulations indicate that
the MRF-X model can map subvoxel parameters in cases
where standard mapping sequences would map a single
effective T1 or T2 value. MRF-X has the potential to
directly measure properties of tissue microstructure.
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