Abstract #0328
Detection of lung mitochondrial dysfunction using hyperpolarized [1-13C] pyruvate metabolism
Hoora Shaghaghi 1 , Stephen Kadlecek 1 , Mehrdad Pourfathi 1 , Sarmad Siddiqui 1 , Maurizio Cereda 2 , Hooman Hamedani 1 , Harrilla Profka 1 , Yi Xin 1 , and Rahim R. Rizi 1
1
Radiology, University of Pennsylvania,
Philadelphia, PA, United States,
2
Anesthesiology
and Critical Care, University of Pennsylvania,
Philadelphia, PA, United States
Mitochondrial dysfunction is associated with various
forms of lung injury and disease. To address the effect
of mitochondrial dysfunction on lung metabolism,
HP-Pyruvate metabolism was studied in presence of
complex I inhibitor (rotenone) and complex IV activator
(TMPD). Rotenone decreased bicarbonate production
significantly (49%) and TMPD elevated it about 74% when
compared to control. Lactate label exchange
significantly increased in treated lungs with rotenone
(53%). Enhancement of lactate production of injured
lungs could be from presence of inflammatory cells
and/or because of mitochondrial dysfunction. But the
bicarbonate production is not changed in inflamed lungs
and decreased on dysfunction of mitochondria.
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