Meeting Banner
Abstract #0336

In vivo Assessment of Cold Stimulation Effects on the Fat Fraction of Brown Adipose Tissue using Dixon MRI

Vanessa Stahl 1 , Florian Maier 1 , Ralf O. Floca 2 , Moritz C. Berger 1 , Mauricio Berriel Diaz 3 , Martin T. Freitag 2 , Marc-Andr Weber 4 , Antonia Dimitrakopoulou-Strauss 5 , and Armin M. Nagel 1

1 Medical Physics in Radiology, German Cancer Research Center, Heidelberg, Germany, 2 Department of Radiology, German Cancer Research Center, Heidelberg, Germany, 3 Molecular Metabolic Control, German Cancer Research Center, Heidelberg, Germany, 4 Diagnostic and Interventional Radiology, University Hospital of Heidelberg, Heidelberg, Germany, 5 Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center, Heidelberg, Germany

Brown adipose tissue (BAT) is subject of ongoing research because of its ability to dissipate energy through non-shivering thermogenesis giving therapeutic potential for the treatment of obesity and metabolic diseases in humans. The purpose of this work was to evaluate in vivo the acute activation of BAT by induced cooling of the skin using Dixon water-fat-separated MRI. The fat fraction (FF) of BAT was determined over time in five volunteers in a temperature-controlled measurement including 90 minutes of cooling time. Focusing on the two interscapular BAT depots, a mean FF decrease of (-4.0 1.7) % / h was detected and therefore FF changes over time in BAT during cooling could be observed.

This abstract and the presentation materials are available to members only; a login is required.

Join Here