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Abstract #0337

Bias in liver fat quantification using chemical shift-encoded techniques with short echo times

Diego Hernando 1 , Utaroh Motosugi 1,2 , and Scott B. Reeder 1,3

1 Radiology, University of Wisconsin-Madison, Madison, WI, United States, 2 Radiology, University of Yamanashi, Yamanashi, Japan, 3 Medical Physics, University of Wisconsin-Madison, Madison, WI, United States

Chemical Shift Encoded (CSE) techniques for fat quantification enable rapid and accurate quantification of proton-density fat-fraction (PDFF), a fundamental biomarker of triglyceride concentration in tissue. However, these techniques suffer from relatively low SNR due to the rapid acquisition with parallel imaging acceleration and the use of very low flip angles. In order to improve the SNR, acquisitions with short echo times (eg: initial TE<1ms) and moderate spatial resolution may be performed. In this work, we show that these acquisitions present elevated signal at short TE, leading to positive bias (1.6%-1.9%) in liver PDFF relative to standard CSE or single-voxel spectroscopy.

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