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Abstract #0339

SLIce Dithered Enhanced Resolution Simultaneous MultiSlice (SLIDER-SMS) for high resolution (700 um) diffusion imaging of the human brain

Kawin Setsompop 1 , Berkin Bilgic 1 , Aapo Nummenmaa 1 , Qiuyun Fan 1 , Stephen F Cauley 1 , Susie Huang 1 , Itthi Chatnuntawech 2 , Yogesh Rathi 3 , Thomas Witzel 1 , and Lawrence L Wald 1

1 Martinos Center for Biomedical Imaging, Charlestown, MA, United States, 2 Massachusetts Institute of Technology, Cambridge, MA, United States, 3 Brigham and Women's Hospital, Boston, MA, United States

Sub-millimeter in vivo diffusion imaging (DI) is extremely challenging. In this work, we propose a new slice encoding strategy that enables 700μm isotropic whole-brain DI at b>1000s/mm2 in a reasonable time. Specifically, we introduce and validate the SLIDER-SMS method, which combines SMS imaging with super resolution via sub-voxel shift in the slice direction. In order to additionally gain high in-plane resolution, we use ZOOPPA to reduce the phase FOV and distortion. We demonstrate that SLIDER-SMS with ZOOPPA can provide high quality 700um whole-brain DI data in 40min, where MB-2 and 3x-SLIDER provides a √6 SNR gain compared to conventional DI.

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