Abstract #0339
SLIce Dithered Enhanced Resolution Simultaneous MultiSlice (SLIDER-SMS) for high resolution (700 um) diffusion imaging of the human brain
Kawin Setsompop 1 , Berkin Bilgic 1 , Aapo Nummenmaa 1 , Qiuyun Fan 1 , Stephen F Cauley 1 , Susie Huang 1 , Itthi Chatnuntawech 2 , Yogesh Rathi 3 , Thomas Witzel 1 , and Lawrence L Wald 1
1
Martinos Center for Biomedical Imaging,
Charlestown, MA, United States,
2
Massachusetts
Institute of Technology, Cambridge, MA, United States,
3
Brigham
and Women's Hospital, Boston, MA, United States
Sub-millimeter in vivo diffusion imaging (DI) is
extremely challenging. In this work, we propose a new
slice encoding strategy that enables 700μm isotropic
whole-brain DI at b>1000s/mm2 in a reasonable time.
Specifically, we introduce and validate the SLIDER-SMS
method, which combines SMS imaging with super resolution
via sub-voxel shift in the slice direction. In order to
additionally gain high in-plane resolution, we use
ZOOPPA to reduce the phase FOV and distortion. We
demonstrate that SLIDER-SMS with ZOOPPA can provide high
quality 700um whole-brain DI data in 40min, where MB-2
and 3x-SLIDER provides a √6 SNR gain compared to
conventional DI.
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