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Abstract #0347

Why should axon diameter mapping use low frequency OGSE? Insight from simulation

Ivana Drobnjak 1 , Hui Zhang 1 , Andrada Ianus 1 , Enrico Kaden 1 , and Daniel C Alexander 1

1 Centre for Medical Image Computing, Department of Computer Science, University College London, London, London, United Kingdom

Imaging axon diameter could provide insight into basic brain operation as well as neuronal diseases that alter axon diameter distribution. This work aims to identify the optimal diffusion MRI sequence that maximizes sensitivity to axon diameter in practical applications. The study shows that although standard PGSE always gives maximum sensitivity for the simple case of gradients perfectly perpendicular to straight parallel fibres, low frequency trapezoidal OGSE provides higher sensitivity in real-world scenarios where fibres have unknown or dispersed orientation. This is a novel fundamental insight into both sequences and their benefits for imaging axon diameter.

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