Why should axon diameter mapping use low frequency OGSE? Insight from simulation

Imaging axon diameter could provide insight into basic brain operation as well as neuronal diseases that alter axon diameter distribution. This work aims to identify the optimal diffusion MRI sequence that maximizes sensitivity to axon diameter in practical applications. The study shows that although standard PGSE always gives maximum sensitivity for the simple case of gradients perfectly perpendicular to straight parallel fibres, low frequency trapezoidal OGSE provides higher sensitivity in real-world scenarios where fibres have unknown or dispersed orientation. This is a novel fundamental insight into both sequences and their benefits for imaging axon diameter.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.