Why should axon diameter mapping use low frequency OGSE? Insight from simulation
Ivana Drobnjak 1 , Hui Zhang 1 , Andrada Ianus 1 , Enrico Kaden 1 , and Daniel C Alexander 1
Centre for Medical Image Computing,
Department of Computer Science, University College
London, London, London, United Kingdom
Imaging axon diameter could provide insight into basic
brain operation as well as neuronal diseases that alter
axon diameter distribution. This work aims to identify
the optimal diffusion MRI sequence that maximizes
sensitivity to axon diameter in practical applications.
The study shows that although standard PGSE always gives
maximum sensitivity for the simple case of gradients
perfectly perpendicular to straight parallel fibres, low
frequency trapezoidal OGSE provides higher sensitivity
in real-world scenarios where fibres have unknown or
dispersed orientation. This is a novel fundamental
insight into both sequences and their benefits for
imaging axon diameter.
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