Assessing Diffusion Time Effects on Microstructural Comparment Estimates in Human White Matter using 7T dwSTEAM

The purpose of this work is to analyse the impact of diffusion time in estimating axonal density and axonal diameters using STEAM diffusion at 7T. Using a 2-ways ANOVA, we demonstrate that the estimates of axonal density obtained at different diffusion times are significantly different. In addition, by accounting for the diffusion time dependency of the extra-axonal signal, we show that estimates of axonal diameter in agreement with histology can be obtained.

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