Abstract #0345
Detection of curvature and microscopic anisotropy of neurites at short length scales
Jonathan Scharff Nielsen 1 , Tim B Dyrby 1 , and Henrik Lundell 1
1
Danish Research Centre for Magnetic
Resonance, Copenhagen University Hospital Hvidovre,
Hvidovre, Denmark
In this work we explore the possibility for performing
micro-anisotropy measurements on fibers with sharp
undulations with double diffusion encoding (DDE) at
short length scales using circularly polarized
oscillating gradient spin echo (CP-OGSE). We show in
simulations that the method is sensitive to anisotropy
and that the curvature can be assessed from the signals
frequency dependence. MRI experiments on post mortem
tissue shows similar behavior. We suggest that the
method can provide a novel contrast for gray matter
complexity.
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