Detection of curvature and microscopic anisotropy of neurites at short length scales

In this work we explore the possibility for performing micro-anisotropy measurements on fibers with sharp undulations with double diffusion encoding (DDE) at short length scales using circularly polarized oscillating gradient spin echo (CP-OGSE). We show in simulations that the method is sensitive to anisotropy and that the curvature can be assessed from the signals frequency dependence. MRI experiments on post mortem tissue shows similar behavior. We suggest that the method can provide a novel contrast for gray matter complexity.

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