Layer-Dependent Calibrated BOLD Response in Human M1

The Davis model for blood oxygenation level dependent (BOLD) signal changes gives the possibility of estimating cerebral metabolic rate of oxygen consumption (CMRO2) changes noninvasively. The increased resolution offered by ultra-high fields (7T) paved the way for layer dependent studies and for the investigation of CMRO2 distribution across cortical layers. Scaled BOLD and vascular space occupancy (VASO) profiles, together with M and CMRO2 estimates in human primary motor cortex, were obtained at high resolution (0.8x0.8x1.5 mm3) and showed a marked change with cortical depth, implying that the assumption of constant values across the cortex should be decisively called into question.

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